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4x1 HD-tDCS Adaptor
4x1 HD-tDCS Adaptor

Reference : 4x1C3


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4x1 HD-tDCS Adaptor



Soterix 4×1 HD-tDCS adaptor converts any 2-channel tDCS stimulator into an HD-tDCS device. The adaptor is not a stand-alone stimulator and during stimulation does not generate any current. The 4×1 HD-tDCS adaptor intelligently divides & guides currents generated by a 2-channel device, converting it to HD-tDCS, thus an ideal solution where an existing 2-channel device is already in use.

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Data sheet

4x1 HD MontageThe most common HD-tDCS deployment. With option to select a center anode or cathode
Integrate with any 1x1 deviceThe Soterix 4×1 HD-tDCS adaptor converts any 2-channel tDCS stimulator into an HD-tDCS device
HD Software CompatibleCompatible with Soterix's revolutionary neurotargeting software: HD-Targets and HD-Explore
IntensityAs set on 1x1
DurationAs set on 1x1
SMARTscanProvides a continuous visual indication of electrode quality before and during stimulation

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High Definition-transcranial Direct Curren Stimulation

High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a transformative technology for targeting cortical and deep brain structures with weak DC currents. Unlike any other neuromodulation technique, HD-tDCS is non-invasive, targeted, and can leverage the therapeutic potential, convenience, safety, and cost-advantages of tDCS. Soterix medical is the exclusive manufacturer of HD-tDCS technology.

Soterix Medical High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive technique where brain regions are targeted using arrays of electrodes on the scalp. In contrast to conventional tDCS, which uses large sponge electrodes, HD-tDCS uses our exclusive Soterix Medical “High-Definition” small gel based electrodes. This proprietary technology is the only hardware that allows safe and tolerated passage of current through small electrodes on the scalp, as validated in clinical trials. HD-tDCS provides users with tremendous flexibility in determining brain targets through the use of Soterix Medical Neurotargeting Software. Fully integrated with every HD-tDCS hardware system, Neurotargeting makes optimized and individualized therapy as easy as a push of a button.

High-Definition transcranial Direct Current Stimulation (HD-tDCS) was invented at The City University of New York with the introduction of the 4x1 HD-tDCS montage (Datta 2009). The 4x1 HD-tDCS montage categorically transformed the possibilities with non-invasive neuromodulation but allowing precise targeting of cortical structures. How focal is 4x1 HD-tDCS? The region of current flow is circumscribed by the area of the 4x ring, such that decreasing ring radius increased focality. Soterix Medical Neurotargeting software makes HD montage design fast and easy. But the innovation did not stop there. Scientists went on to demonstrate that 4x1 HD-tDCS allow for unifocal stimulation, meaning the polarity of the center 1x electrode will determine the direction of neuromodulation under the ring (Villamar 2013). This is in contrast to conventional tDCS where the need for one anode and one cathode always produces bidirectional modulation (even when an extra-cephalic electrode is used). 4x1 HD-tDCS thus provides the ability not only to select a cortical brain region to target, but to modulate the excitability of that brain region with a designed polarity without having to consider return counter-electrode flow.

There is only one electrode design that has been engineered for HD-tDCS, validated in extensive clinical testing, and used in clinical trials. The High Definition electrode was designed at The City University Of New York (Minhas 2010) and been proven safe and well tolerated in multi-center clinical trials (Borckardt 2012, Villamar 2013, Kuo 2013). It is critical investigators do not attempt multi-electrode stimulation with non-validated “off-brand” devices under the assumption these approaches have any relevance to Soterix Medical HD-tDCS technology or clinical validated approaches. Use of off-brand electrodes and devices compromise research integrity, patient safety, and interferes with the rational development of HD-tDCS by the research community.

A critical question given the targeting of 4x1 HD-tDCS is “when is focality desired?” There is no simple answer to this question but is it important to recognize that most conventional tDCS approach produce current flow through >50% of the brain including deep brain structures and that with conventional tDCS inter-individual anatomical difference means the location of peak brain electric field will vary widely. Therefore, by guaranteed peak brain electric field at the target and restricting brain current flow to a limited region, 4x1 HD-tDCS confers some theoretical clinical benefits. In ongoing clinical trials, 4x1 HD-tDCS has consistently produced effects size comparable or exceeding alternative neuromodulation protocols, including in control of experiment and clinical pain (Borckardt 2012, Villamar 2013). More striking, in a direct comparison with conventional tDCS, Nitsche and Paulus demonstrated that 4x1 HD-tDCS produce change in brain excitability that significantly exceed both the magnitude and duration of conventional tDCS (Kuo 2013).

In advanced neuromodulation design, software and hardware that allows arbitrary placement of HD electrodes on the head is required. Precision of montage matters critically, which is why stimulation software and supporting hardware must provide user with flexibility and precision in control. Don't be confused by copycat hardware and software that provides neither flexibility nor precision. State-of-the-art neurotargeting software and hardware, with flexibility and precision, exclusively from the industry leader in non-invasive electrical stimulation, Soterix Medical.

Soterix Medical tDCS Highlights

  • The only hardware validated for safe and tolerated stimulation in multi-center clinical trials.

    Other technologies and devices marketed for “small electrode transcranial stimulation” are not endorsed by Soterix Medical and are counter-indicated for use with any Soterix Medical stimulator or software, including 4x1 HD-tDCS. Soterix Medical is committed to the advancement of rational non-invasive neuromodulation through application of the highest scientific and medical standards.

  • Exclusive Neurotargeting Software for dose optimization.

    Given the flexibility of HD-tDCS, with independently controlled electrodes deployed anywhere on the head, software that allows simple and optimized set-up is critical. Soterix Medical developed Neurotargeting Software exactly for this purpose including a range of exclusive features all designed to make dose optimization for your clinical trial simple and convenient.

  • Conduct clinical studies with state-of-the-art control and safety features.

    Soterix Medical developed HD-tDCS and clinicians trust our team of scientists and biomedical engineers to ensure every HD-tDCS devices if designed and manufactured based on the most state-of-the-art evidence and techniques. Soterix Medical is the industry standard for non-invasive brain stimulation and nowhere is this more important than in HD-tDCS.

  • Provide for simple and comfortable set-up and stimulation.

    Usability and simplicity underpin every Soterix Medical device and HD-tDCS is no exception. We recognize that state-of-the-art neuromodulation tools are only as effective as they can be understood and controlled by operators. Our human factors engineers review every aspect of HD-tDCS stimulator and accessories to ensure that advanced neuromodulation does not come at the cost of complexity in use. Our unparalleled customer support ensures you have all the guidance and support, when you need it.

4x1 HD-tDCS Adapter

The most economical and scalable solution for HD-tDCS.

The Soterix 4×1 HD-tDCS adaptor converts any 2-channel tDCS stimulator into an HD-tDCS device. The 4×1 HD-tDCS adaptor is not a stand-alone stimulator, and during stimulation does not generate any current. Rather, the 4×1 HD-tDCS adaptor intelligently divides and guides current generated by a 2-channel device, converting it to HD-tDCS. The Soterix 4×1 HD-tDCS adaptor is thus an ideal solution where an existing 2-channel device is already in use.

Soterix 1x1 tDCS converted to 5-channel HD-tDCS using the Soterix 4x1 Adaptor

The Soterix 4×1 HD-tDCS adaptor converts any 2-channel tDCS stimulator into an HD-tDCS device. The 4×1 HD-tDCS adaptor is not a stand-alone stimulator, and during stimulation does not generate any current. Rather, the 4×1 HD-tDCS adaptor intelligently divides and guides current generated by a 2-channel device, converting it to HD-tDCS. The Soterix 4×1 HD-tDCS adaptor is thus an ideal solution where an existing 2-channel device is already in use.

The Soterix 4×1 HD-tDCS adaptor is fully compatible with HD-tDCS accessories and each 4×1 HD-tDCS adaptor comes with one connector cable (specify your 2-channel device, if not a Soterix 1x1 tDCS, when ordering).

How it Works

The 4×1 HD-tDCS adaptor interface is an accessory to an isolated 2-channel tDCS stimulator and does not function as a stand-alone electrical stimulator or generator. The 4×1 HD-tDCS adaptor device is designed to be used as an interface device between an isolated 2-channel current controlled tDCS stimulator and 5 stimulation leads; where 4 leads (colored) are connected to one output of the tDCS stimulator and the remaining lead (white) is connected to the other output of the tDCS stimulator. The output leads connect to smaller high-definition (HD) electrodes, instead of the larger sponge electrodes using in conventional 2-channel tDCS. The device operates in two modes: SCAN and PASS mode. In PASS MODE, the 4×1 HD-tDCS adaptor does not modulate the waveform of the tDCS stimulator, and acts only as a passive current divider. In SCAN mode, the device uses exclusive HD electrode impedance mapping technology to ensure proper set-up prior to stimulation.

Device Features

Each Soterix Medical HD-tDCS feature was developed by our team of biomedical engineers consulting closely with leading clinical centers. Designed to simply set-up, provide intelligent warning of a fault condition, and allow for adjusting for patient comfort , these features facilitate reliable and tolerated HD-tDCS. The Soterix Medical SmartScan™ feature is central in all HD-tDCS and tDCS devices to allow reliable set-up and monitoring.

SMARTscanFrom pre-stimulation set-up, to during stimulation monitoring, to post-stimulation confirmation, the Soterix Medical SmartScan™ feature provides an intuitive and clear indication of electrode contact quality. Use the SmartScan™ during set-up to adjust electrodes and head-gear for optimal fit. During stimulation, SmartScan™ provides a constant indication of electrode quality and can be monitored during adjustments (e.g. addition of saline to drying electrodes). After stimulation, SmartScan™ confirms a successful trial. Because “resistance” is not meaningful for tDCS, SmartScan™ was developed by Soterix Medical engineers to provide clinical investigators with a simple to read indication of contact quality.

The back-lit display can be monitored during stimulation ramp up and to confirm target current intensity is achieved.


An automatic stimulation sham feature that is engaged with a simple switch. Auto-sham automatically calculated and produces a sham waveform based on the the indicated “real” waveform. For example, for a corresponding real waveform of 1.5 mA and 10 minutes. auto-sham will provide a ramp up/down to 1.5 mA at the start of of stimulation, and again after 10 minutes, with the timer automatically adjusted such that the total run time us exactly matched to the real case. Based on the Soterix Medical OpenPanelTM design principle: with no complicated programming or hidden drop-down menus required.

HD Monitor

An exclusive technology from the trusted leader in neuromodulation, Soterix Medical HD-monitor is an intelligent oversight system that provides continues monitoring of current flow conditions and can engage automatic ramp-down should unusual performance be detected. HD-tDCS is the most advanced non-invasive neuromodulation system, providing tremendous flexibility to operators. HD-monitor provides a further level of automatic over-sight before, during, and after stimulation.

HD Software

Multichannel stimulation devices are only as customizable as the software used to design montages. With independent current control at each electrode with MxN devices, device power and flexibility requires intelligent montage design software. Neurotargeting software is the exclusive Soterix Medical solution to montage design and our HD-tDCS stimulator integrate seamlessly. Clinicians and scientists trust Soterix Medical engineers to provide the modeling and software sophistication to fully leverage HD-tDCS.

SMI 4x1

The 4x1 HD-tDCS montage remains the more popular and validated montage for unidirectional targeted brain neuromodulation. Devices optimized for 4x1 are designed to allow simple and consistent set-up including in high throughput clinical trials. Simple to use and designed by the inventors of 4x1 HD-tDCS, do not be confused by copycats and compromise the integrity of your trial and safety of your subjects. Soterix Medical Inc. (SMI) 4x1 certification is indicated on all validated 4x1 devices. *All MxN devices can provide 4x1 stimulation in addition to arbitrary configurations.


Tickle™ may be used to both condition skin prior to tDCS and for naïve subject anxious about stimulation. A custom on-off waveform pattern generates mild and brief sensation under electrodes


Based on feed-back from leading clinical centers, Soterix Medical exclusive feature Relax™ accommodates subjects who may be anxious when stimulation is initiated or during the course of stimulation. The Relax™ slider may be adjusted from full to reduced intensity based on subject perception without interrupting or aborting stimulation.

Four design principles of OpenPanel™ Device Interfaces

To understand the Soterix Medical's OpenPanel interface, one needs to consider how tES and tDCS are applied in the best clinical and academic centers. The risk of relying on a wireless connection with a computer to control and monitor the device is not acceptable. Similarly, complex and hidden drop-down menus create inherent risk in programming mistakes. A single mistake can compromise subject safety and the integrity of an entire clinical trial. For medical grade equipment, device status and subject monitors should be clearly visible on the device display. Soterix Medical devices, including features such as OpenPanel, are chosen when patient tolerability and trial integrity cannot be compromised.

OpenPanel™ Reproducibility Advantage

No drop down menus.
No hidden setting.

Avoid confusion and mistakes. Save time. 1x1 devices can be programmed in seconds with simple switches and controls.

No external computer.
All devices stand alone.

With stand-alone 1x1 stimulators, there is never a need to use a personal computer for interface. This reduces your cost, complexity and potential errors.

Elevated panels.
Backlit displays.

Easy to read displays, even at a distance and even in reduced light conditions, means you always can monitor stimulation status.

Optimized devices.
Customized interfaces.

In advanced neuromodulation, one size does not fit all. Display and control items are minimized to what you need. Clarity and simplicity without compromise.

OpenPanel™ Safety Advantage

A single programming error undermines reproducibility and safety of an entire trial. OpenPanel reduces errors even under multiple-user or high-throughout conditions.

No risk of computer or connection failure leading to loss of device control. Risks associated with computer failure (e.g. during a software update) are avoided.

Device settings and current state are always visible to their operator. Intelligent SmartScan testing provides early warning of poor contact conditions.

Devices prevent current transients even under unexpected conditions such as sudden re/dis-connection. Soterix Medical is the trusted leader in tES by designing safety factors for the unexpected.

Revolutionary Neurotargeting Software

Optimization of electrode montage for brain targeting and individual subject customization has never been as easier as with Soterix Medical's Neurotargeting software. With recognition that placing an electrode "over" a target dose not support rational tDCS does design, the Soterix Medical Suite of software tools allow simple and automatic optimization. Soterix Neurotargeting software also provides high-resolution current flow visualization that can be used to support publications, presentation and proposals.

Feel free to contact our engineers at Caputron to assist you with your endeavors, we would love to help!


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4x1 HD-tDCS Adaptor

4x1 HD-tDCS Adaptor

Soterix 4×1 HD-tDCS adaptor converts any 2-channel tDCS stimulator into an HD-tDCS device. The adaptor is not a stand-alone stimulator and during stimulation does not generate any current. The 4×1 HD-tDCS adaptor intelligently divides & guides currents generated by a 2-channel device, converting it to HD-tDCS, thus an ideal solution where an existing 2-channel device is already in use.

Write a Review